This study was designed to ascertain the antioxidant and in-vivo antihyperglycemic property of leaves extracts of Wendlandia thyrsoidea (R. and S.) Steud. in streptozotocin-nicotinamide induced type 2 diabetic in rats model. 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging capacity, reducing power, total antioxidant capacity, scavenging of H2O2 and metal chelating ability for ferrous ions were used to screen the antioxidant properties of extracts. Streptozotocin-nicotinamide induced type 2 diabetic in rats model was used to screen antihyperglycemic property. The extracts showed significant antioxidant activity in correlation to extracts phytoconstituents. The IC50 value for antioxidant property of aqueous extract of leaves was found to be 49.33±1.79 µg/ml by DPPH radical scavenging, 77.53±2.07 µg/ml by Fe2+ chelating activity and 100.70±1.31 µg/ml for scavenge H2O2. The significant decreasing blood glucose level and increasing in body weight on treatment with extracts on streptozotocin-nicotinamide induced type 2 diabetic rats implies the anti-hyperglycemic activity of leaves. The obtained results showed the plant have potential antioxidant and antihyperglycemic property and suggesting further study to isolate the compound responsible for the biological activity.
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